df.rename(columns={"old_col1": "new_col1", "old_col2": "new_col2"})
>>> df = pd.DataFrame({"A": [1, 2, 3], "B": [4, 5, 6]}) >>> df.rename(columns={"A": "a", "B": "c"}) a c 0 1 4 1 2 5 2 3 6